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NEAL A. VANSELOW, JOSEF R. SMITH; Bronchial Asthma Induced by Indomethacin. Annals of Internal Medicine. 1967 Mar;66(3):568-572.

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Case Reports | 1 March 1967

Bronchial Asthma Induced by Indomethacin

NEAL A. VANSELOW, M.D.; and JOSEF R. SMITH, M.D., F.A.C.P.

Ann Intern Med. 1967;66(3):568-572. doi:10.7326/0003-4819-66-3-568

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Indomethacin is a nonsteroid chemical compound with anti-inflammatory, antipyretic, and analgesic properties. It has been widely employed in the treatment of certain musculoskeletal disorders including rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, and gout (1). Indomethacin is not chemically related to the salicylates and has been used by some to supplement or replace aspirin in cases where the latter is ineffective or poorly tolerated. The major adverse reactions associated with indomethacin therapy involve the central nervous system (headache, lightheadedness, vertigo, mental confusion) and the gastrointestinal tract (nausea, indigestion, epigastric burning, diarrhea, peptic ulceration, occult gastrointestinal bleeding) (1-3). Angioneurotic edema, tinnitus, blurred vision,

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