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Calcified Megakaryocytes in a Case of Thrombocytopenia

Ann Intern Med. 1967;66(4):752-755. doi:10.7326/0003-4819-66-4-752
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While nonspecific changes in the megakaryocytes are well recognized in idiopathic thrombocytopenic purpura, calcification has not been previously reported. In the following case, thrombocytopenia with severe bleeding was resistant to all treatment, and at autopsy specific calcification of the megakaryocytes was found.

CASE REPORT: A 22-year-old white woman (BCH 2007994) was admitted to the Boston City Hospital because of hemorrhage and weakness. Her first admission, 15 months previously, had been for eclampsia with delivery of a stillborn infant by cesarean section. Except for a transient generalized macular rash in December 1964 she was well until May 1965, when she had


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