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Epidemiology of Fatal Systemic Sclerosis (Diffuse Scleroderma): A 15-Year Survey in Baltimore

Ann Intern Med. 1967;66(5):870-883. doi:10.7326/0003-4819-66-5-870
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Little is known about the factors that predispose to systemic sclerosis (diffuse scleroderma) or that influence its usually progressive and fatal outcome. Epidemiologic studies, which relate cases to a defined community population, may reveal clues to personal, socioeconomic, or environmental determinants in this disease of unknown cause. A community-wide survey, furthermore, promises a larger and more representative sample of cases than might be found at a single institution. This improved sample of patients offers a better opportunity to define the characteristics and natural history of the disease.

No previous population study of systemic sclerosis has been reported, and this paper


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