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Precipitous Fall in Serum Calcium, Hypotension, and Acute Renal Failure After Intravenous Phosphate Therapy for Hypercalcemia: Report of Two Cases

Ann Intern Med. 1967;66(5):906-916. doi:10.7326/0003-4819-66-5-906
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In a search for more effective forms of therapy for hypercalcemia, Goldsmith and Ingbar (1) have recently focused on the use of oral or parenteral phosphate. They reported a series of 20 hypercalcemic patients in whom phosphate safely lowered the serum calcium. Subsequently, two additional patients were reported in whom transient hypocalcemia was observed after intravenous phosphate infusion; caution with this form of therapy was advised (2).

We wish to extend this note of caution further, in view of the precipitous decrease in serum calcium associated with hypotension and acute renal failure after therapy with intravenously administered phosphate buffer in


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