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Original Research |

The Absorption of Calcium Carbonate

Ann Intern Med. 1967;66(5):917-923. doi:10.7326/0003-4819-66-5-917
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Although calcium carbonate (CaCO3) is widely used in the treatment of peptic ulcer disease and is freely available on the open market, relatively little information about its absorption is available. It has often been assumed that, because CaCO3 is insoluble in water, calcium given in this form is not appreciably absorbed. However, significant hypercalcemia and alkalosis are observed occasionally among persons treated with CaCO3 (1,2), and in a controlled study, hypercalcemia was found to be a frequent complication of this form of treatment (3). Furthermore, some patients treated with milk and alkali develop irreversible renal damage and calcifications of the


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