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Pseudomonas Polysaccharide (Piromen®) in the Evaluation of the Hypothalamus-Pituitary-Adrenal Cortical Axis.

W. D. Hawley, M.D. (Associate); and C. Y. Bowers, M.D., F.A.C.P.
Ann Intern Med. 1967;66(5):1028. doi:10.7326/0003-4819-66-5-1028_1
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A commercially available nonprotein polysaccharide-nucleic acid complex prepared from Pseudomonas (Piromen®) is used as a standardized stimulus to evaluate the function of the hypothalamus-pituitary-adrenal cortical axis in hospitalized or ambulatory patients. The test is performed as follows: 2.5 ml plasma are obtained from blood collected in a heparinized vacuum tube at 8 AM after an overnight fast; Piromen, 0.1 µg/kg of body weight, is given intravenously; and 2.5 ml of plasma are obtained 2 hr later. Plasma cortisol concentration is determined by a fluorometric procedure. Simplicity and lack of serious side effects recommend the test for a variety of studies.


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