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Cytogenetic Studies in Multiple Myeloma.

John R. Durant, M.D., F.A.C.P.; and Ernest M. Tassoni, M.D.
Ann Intern Med. 1967;66(5):1041. doi:10.7326/0003-4819-66-5-1041_1
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In the past 3 years the bone marrows of 14 patients with unequivocal multiple myeloma were subjected to cytogenetic study. All had at least 20 clear, scorable metaphase plates. Five had a morphologically similar, large, acrocentric marker chromosome whose size was approximately that of the long arms of a B group chromosome present in most of their karyotypable hyperdiploid cells. Two had a similar, but either lightly stained or despiralized, chromosome in the majority of the hyperdiploid cells that were scored. One patient had a large, submetacentric marker present in several of his hyperdiploid metaphase plates. No other consistent abnormality


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