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Enhancement by Hydrocortisone of Mouse Hepatitis Virus Replication in Primary Macrophage Cultures.

Seymour M. Sabesin, M.D.; Dharam V. Datta, M.D.; and Kurt J. Isselbacher, M.D.
Ann Intern Med. 1967;66(5):1048. doi:10.7326/0003-4819-66-5-1048_1
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Although corticosteroids are sometimes used in the treatment of viral hepatitis, there is considerable experimental evidence that cortisone adversely affects the susceptibility of mice to viral hepatitis.

To better understand the mechanism of corticosteroid action on hepatitis viruses, studies were performed in tissue culture using mouse peritoneal macrophages, as host cells, since macrophages may control the susceptibility of the liver to viral infection by regulating the entry of viruses into the target organ. The effects of hydrocortisone on mouse hepatitis virus (MHV) infection were evaluated by observing the onset and severity of cytopathogenic changes (CPE) and by biochemically quantitating the


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