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Abstracts |

Renin Activity in Patients with End-Stage Kidney Disease.

Norman Lasker, M.D.; Gilbert E. Levinson, M.D., F.A.C.P.; Michael Gutkin, M.D.; and Anthony S. King, M.D.
Ann Intern Med. 1967;66(5):1051. doi:10.7326/0003-4819-66-5-1051_2
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Patients with end-stage renal disease maintained on chronic dialysis have an exaggerated hypertensive response to overhydration which has been found to be partially corrected by bilateral nephrectomy and completely corrected by successful renal transplantation. The possibility that renin contributes to this phenomenon was investigated by measuring renin activity in overhydrated hypertensive patients with end-stage kidney disease before and after hypertonic, eunatremic (4.25% glucose, 140 mEq/liter Na+) and less hypertonic, hyponatremic (2.0% glucose, 114 mEq/liter Na+) peritoneal dialysis.

Blood pressure was measured by auscultation or a Statham strain gauge and plasma volume, by Evans blue or 131I albumin. Body weight, Na+,

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