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First Dorsal Interosseous Muscle Atrophy: A Clinical Sign of Impaired Glucose Metabolism.

Harry Bienenstock, M.D. (Associate); Sheldon J. Davidson, M.D.; and Thomas J. Forschner, M.D.
Ann Intern Med. 1967;66(5):1057. doi:10.7326/0003-4819-66-5-1057_1
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Over a 16-month period, four patients were referred to the Rheumatology Division because of bilateral first dorsal interosseous muscle atrophy, diagnosed as "arthritis." Two of these patients were known to have diabetes mellitus, and two had abnormal oral glucose tolerance tests upon further study.

In order to test whether first dorsal interosseous atrophy was an indicator of impaired glucose metabolism, medical and surgical inpatients, exclusive of those with arthritis and neuromuscular disease, were asked to show their hands to two independent examiners. No history was elicited until after the hands were inspected and evaluated. Thirty-two patients (group I) exhibited bilateral


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