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Recent Studies of Alcoholic Myopathy, Including Electron Microscopy.

Gerald T. Perkoff, M.D., F.A.C.P.; Virgil Bleisch, M.D.; George Klinkerfuss, M.D.; and Marconi Dioso, M.D.
Ann Intern Med. 1967;66(5):1064. doi:10.7326/0003-4819-66-5-1064_1
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Several muscular abnormalities exist in alcoholism. Studies reveal biochemical alterations in asymptomatic alcoholic patients, acute myopathies, and a chronic proximal myopathy. We report here experience with 48 asymptomatic alcoholics, 6 with acute myopathy (1 with gross myoglobinuria, 5 with severe cramps or tenderness or both and weakness) and 10 with chronic myopathy. Transition from acute to chronic myopathy was observed.

Many asymptomatic alcoholics described muscle cramps in the past; 36 out of 48 had elevated serum creatine phosphokinase (CPK). Other changes included abnormal lactic acid responses to ischemic exercise and micromyoglobinuria (detected by immunodiffusion). The patient with gross myoglobinuria and


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