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Treatment of Breast Cancer with Medroxyprogesterone.

Franco M. Muggia, M.D.; Peter A. Cassileth, M.D.; Frederick A. Flatow, M.D.; Alfred A. Gellhorn, M.D., F.A.C.P.; George A. Hyman, M.D., F.A.C.P.; and Manuel Ochoa Jr., M.D.
Ann Intern Med. 1967;66(5):1066. doi:10.7326/0003-4819-66-5-1066_1
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The observation that progestational agents alone or combined with estrogens might be useful in the management of cancer led to the treatment of 36 patients (34 women and 2 men) with disseminated breast cancer with medroxyprogesterone acetate (Provera®). Patients were selected from two groups: In one, relapse had occurred after treatment with ablative surgery or conventional hormonal and chemotherapeutic agents; in the other, primary estrogen therapy was limited by intolerance or cardiovascular disease. Provera (100 mg) was administered intramuscularly three times weekly or by mouth daily for at least 5 weeks.

Of the 27 patients receiving adequate treatment, 7 had


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