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Glucagon Provocative Test for Pheochromocytoma

Ann Intern Med. 1967;66(6):1091-1096. doi:10.7326/0003-4819-66-6-1091
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Although diagnosing pheochromocytoma has been greatly assisted by recent advances for the chemical determination of urinary pressor amines, the paroxysmally secreting form may, nevertheless, offer formidable obstacles to early diagnosis. To this end the pharmacologic provocative tests can still prove indispensable. Histamine is probably the most familiar agent used for this purpose (1). Recently, Engelman and Sjoerdsma (2) described a differing pressor response to titrated doses of tyramine useful in distinguishing pheochromocytomas from other forms of hypertension. More recently, I reported that glucagon, the hyperglycemic, glycogenolytic peptide secreted by the alpha cells of the islets of Langerhans, evokes striking pressor


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