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Cephaloridine and Penicillin G in the Treatment of Pneumococcal Pneumonia: A Comparative Study

Ann Intern Med. 1967;66(6):1109-1115. doi:10.7326/0003-4819-66-6-1109
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Although penicillin G remains the drug of choice for the treatment of pneumococcal infections in individuals not hypersensitive to it, the potential role of other antimicrobial agents in the management of such infections is of interest for two reasons. First, these agents may be useful as alternatives in the treatment of patients sensitive to penicillin G. Second, it is important to know whether they are comparably effective in eradicating pneumococcal infection unrecognized because of lack of facilities for bacteriologic study.

Cephaloridine* is a semisynthetic derivative of cephalosporin C related chemically to cephalothin (1). Like cephalothin, it has a broad antimicrobial


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