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Serum Insulin, Carbohydrate, and Lipid Abnormalities in Patients with Premature Coronary Heart Disease

Ann Intern Med. 1967;67(1):42-47. doi:10.7326/0003-4819-67-1-42
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Abnormal glucose metabolism and elevated serum lipids have been intimately related to atherosclerosis. Coronary atherosclerosis is more prevalent in diabetics than in nondiabetics (1). Conversely, hyperglycemia is commonly found in patients suffering from peripheral or coronary atherosclerosis (2). Elevated levels of serum cholesterol and triglycerides have been shown to be associated with coronary heart disease (CHD) (3, 4).

The serum insulin response to glucose in maturity-onset diabetes is characterized by a delayed secretion, and the levels are often elevated. Abnormal insulin responses have also been noted in association with high plasma triglycerides independent of clinical diabetes (5). Obesity, another condition


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