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A Spectrum of Myopathy Associated with Alcoholism: I. Clinical and Laboratory Features

GERALD T. PERKOFF, M.D., F.A.C.P.; MARCONI M. DIOSO, M.D.; VIRGIL BLEISCH, M.D.; and GEORGE KLINKERFUSS, M.D.
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Copyright ©, 1967, by The American College of PhysiciansThe American College of Physicians


Ann Intern Med. 1967;67(3_Part_1):481-492. doi:10.7326/0003-4819-67-3-481
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Hepatic, neurologic, cardiac, hematologic, and metabolic abnormalities are generally accepted as frequent occurrences in people who drink alcoholic beverages (1-5) to excess. That muscle disease may occur in alcoholism is not as widely known. However, myoglobinuria with severe muscle tenderness and swelling, fever, increased levels of serum glutamic-oxalo-acetic transaminase (SGOT) and other enzymes, and, often, acute renal failure has been reported in several alcoholic patients after severe drinking bouts (6-11).

More recently, we reported studies (12) of a similar but less severe syndrome characterized by muscle tenderness and cramps, increased serum creatine phosphokinase (CPK), and a diminished ability to increase

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