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Role of Lupus Erythematosus Factor and Accessory Serum Factors in Production of Extracellular Nuclear Material

Ann Intern Med. 1967;67(4):780-790. doi:10.7326/0003-4819-67-4-780
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Since the original description of the lupus erythematosus (LE) cell by Hargraves, Richmond, and Morton (1), it has become clear that this inclusion-containing cell is formed in two stages (2, 3). In the first stage an abnormal gamma G globulin, the LE factor, reacts with a component of the nucleus, apparently the deoxyribonucleic acid-histone complex (4), to form nuclear material that is altered in appearance. This altered nuclear material may then be phagocytized in the second stage to form LE cells, or it may remain extracellular. This altered extracellular nuclear material (ECM) (5) takes several forms, the most commonly recognized


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