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Gastric Secretion in Ulcerogenic Tumors of the Pancreas

RICHARD D. RUPPERT, M.D.; NORTON J. GREENBERGER, M.D.; FLOYD M. BEMAN, M.D.; and FRANK M. MCCULLOUGH, M.D.
Ann Intern Med. 1967;67(4):808-815. doi:10.7326/0003-4819-67-4-808
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Eleven years have elapsed since Zollinger and Ellison (1) reported the association of peptic ulcer disease and tumors of the pancreas. To date, over 400 cases have been reported. However, it is not generally appreciated that four of the commonly used tests of gastric acid secretion may not suggest the correct diagnosis. Normal values have been reported for basal acid secretion, histamine-stimulated acid secretion, the ratio of basal/stimulated acid secretion, and 12-hr overnight acid secretion in patients with ulcerogenic tumor of the pancreas (2, 3). We have studied gastric secretion in five patients with Zollinger-Ellison syndrome and in 300 other

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