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The "Lucio Phenomenon" in Diffuse Leprosy

Ann Intern Med. 1967;67(4):831-836. doi:10.7326/0003-4819-67-4-831
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The "Lucio phenomenon" is a rare but distinctive skin eruption that is found in patients with diffuse leprosy (1, 2) but that because of its rarity may not be recognized. Diffuse leprosy, a form of lepromatous leprosy occurring in patients with little or no resistance to the infection, rarely occurs outside Mexico and Costa Rica on the North American continent (3). Only two previous cases have been reported from the continental United States (4, 5). In this condition, the skin is diffusely infiltrated by histiocytes and leprosy bacilli (Mycobacterium leprae) instead of developing the typical nodular skin lesions of lepromatous


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