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The Physiologic Basis for Therapy of Classic Hemophilia (Factor VIII Deficiency) and Related Disorders: Combined Clinical Staff Conference at the National Institutes of Health

N. RAPHAEL SHULMAN, M.D.; DALE H. COWAN, M.D.; EUGENE P. LIBRE, M.D.; STANLEY P. WATKINS JR., M.D.; and VICTOR J. MARDER, M.D.
Ann Intern Med. 1967;67(4):856-882. doi:10.7326/0003-4819-67-4-856
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Dr. N. Raphael Shulman: In the past few years much new information has been acquired concerning the pathophysiology and therapy of classic hemophilia and other diseases involving factor VIII deficiency. Most important has been a revolution in treatment permitted by the availability of factor VIII concentrates. Hemostasis in hemophiliacs, which several years ago presented a difficult if not hopeless problem, now can be managed with complete effectiveness in a rather routine manner. In addition, there is a clearer concept of the genetic control of factor VIII, provided chiefly by studies of von Willebrand's disease; and recently, there have been some

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