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Uric Acid Nephrolithiasis in Gout: Predisposing Factors

TS'AI-FAN YÜ, M.D.; and ALEXANDER B. GUTMAN, M.D., F.A.C.P.
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Copyright ©, 1967, by The American College of PhysiciansThe American College of Physicians


Ann Intern Med. 1967;67(6):1133-1148. doi:10.7326/0003-4819-67-6-1133
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It has been known since the time of Galen that the gouty are singularly subject to stone; indeed, the prevalence of uric acid urolithiasis among the gouty is of an order 1,000 times greater than in the nongouty, occurring in 10 to 20% of cases of primary gout in the United States (1) as compared to an estimated incidence of about 0.01% in the population of the country as a whole.* In our own experience, which to be sure is somewhat weighted by inclusion of a number of cases referred specifically for medical management of stone, 280 of 1,258 patients

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