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Infarction of Bone Marrow in the Sickle Cell Disorders

Ann Intern Med. 1967;67(6):1195-1200. doi:10.7326/0003-4819-67-6-1195
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Painful crises in the sickle cell disorders may be produced by capillary stasis, venous thrombosis, or arterial emboli (1). The latter may be caused by escape of aggregated sickled cells from dilated capillaries or venules or by particles of fat or bone marrow that are believed to arise from areas of medullary bone infarction. Bone marrow infarction has been described at autopsy in many reports of patients with the sickle cell disorders (2-5). Ample clinical and roentgenologic evidence suggests that similar changes occur in patients who survive episodes of pain, but that suggestion has not been documented in reported cases


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