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Goodpasture's Syndrome: Cessation of Pulmonary Hemorrhage After Bilateral Nephrectomy

R. K. MADDOCK JR., M.D.; L. E. STEVENS, M.D.; K. REEMTSMA, M.D.; and H. A. BLOOMER, M.D., F.A.C.P.
Ann Intern Med. 1967;67(6):1258-1264. doi:10.7326/0003-4819-67-6-1258
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In its characteristic form Goodpasture's syndrome is a disease of young white men, who develop fulminating glomerulonephritis, hemorrhagic pneumonitis, and severe anemia. The affliction is usually fatal within a few months, the victim dying in uremia or of massive pulmonary hemorrhage. The consistent clinical course and the histologic findings establish Goodpasture's syndrome as a specific disease, distinct from other disorders involving kidney and lung such as periarteritis nodosa and idiopathic pulmonary hemosiderosis (1). However, the etiology is unknown, the connection between the renal and pulmonary manifestations has not been defined, and treatment is usually unsuccessful.

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