The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Cryoprecipitate Concentrates of Factor VIII for Surgery in Hemophiliacs

Ann Intern Med. 1968;68(1):39-47. doi:10.7326/0003-4819-68-1-39
Text Size: A A A

Pool's original method of preparing cryoprecipitate for treating hemophilia was found to be suitable for preparing factor VIII from acidified plasma that is a by-product of platelet concentrates. Preparation of cryoprecipitate was simplified by using residual ice crystals as a collecting filter to eliminate centrifugation and as a suspending medium to eliminate exogenous diluent. Experience with four hemophiliacs undergoing seven surgical procedures is described. Satisfactory factor VIII levels were easily maintained with cryoprecipitate in all patients, and no complications were associated with its use. Recovery of factor VIII in vitro and in vivo is evaluated, and therapeutic regimens that allow for variations in yield to assure hemostasis without laboratory control are outlined. Cryoprecipitate is superior to plasma and as effective as commercially available factor VIII concentrates but cheaper.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
The history of hemophilia. Semin Thromb Hemost 2014;40(5):571-6.
Cryoprecipitate therapy. Br J Anaesth Published online Jun 27, 2014.;
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.