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An Enzyme Defect in Metabolic Gout

Ann Intern Med. 1968;68(3):707-708. doi:10.7326/0003-4819-68-3-707
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Gout is now recognized as a syndrome with numerous causes rather than as a distinct disease entity. With the recognition of more and more conditions associated with hyperuricemia and gout, the simple classification into primary or idiopathic gout and gout secondary to hemopoietic overactivity has lost its usefulness. A number of patients with hyperuricemia unassociated with any other disease are known to produce excessive quantities of urate—the overproducers—while other clinically similar patients without appreciable renal disease have been shown to excrete less urate than normal—the underexcretors. A further group seems to demonstrate features of both of these defects.

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gout ; enzymes

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