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Myopathy in Primary Hyperparathyroidism: Observations in Three Patients

BOY FRAME, M.D., F.A.C.P.; EDWARD G. HEINZE JR., M.D.; MELVIN A. BLOCK, M.D.; and GORDON A. MANSON, M.D.
Ann Intern Med. 1968;68(5):1022-1027. doi:10.7326/0003-4819-68-5-1022
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SUMMARY:

In contrast to tne frequent occurrence of subjective muscle weakness and fatigue, objective muscle weakness and atrophy simulating polymyopathy have infrequently been reported in hyperparathyroidism but may be one of the early and dominant features of this endocrine abnormality. In three such cases reported, two patients had electromyograms suggestive of a myopathy, and one had increased creatinuria that was normal after corrective parathyroid surgery. In one of the patients a muscle biopsy in the preoperative period demonstrated evidence of myositis. Surgical correction of uncomplicated hyperparathyroidism produced prompt improvement in the muscle syndrome due to hyperparathyroidism.

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