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Abstracts |

The John Phillips Memorial Lecture: Urokinase.

Sol Sherry, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1139-1140. doi:10.7326/0003-4819-68-5-1139_3
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Though a safe and reliable form of thrombolytic therapy has not yet been established, progress continues in achieving this objective. Current interest centers about urokinase, a promising thrombolytic agent obtained from human urine. Since a major clinical trial to evaluate urokinase in the treatment of acute pulmonary embolism is scheduled to begin shortly, this presentation described the agent's development. The latter, requiring the close cooperation of the scientific community, the pharmaceutical industry, and the National Heart Institute, has resulted in [1] the production of preparations suitable for clinical investigation; [2] evidence that the intravenous administration of the agent produces a




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