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The American College of Physicians Award Lecture: The Central Nervous Mechanisms Involved in Pyrogen Fever.

Philip Bard, Ph.D.
Ann Intern Med. 1968;68(5):1140. doi:10.7326/0003-4819-68-5-1140_2
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That bodily changes evoked by pyrogen are those exhibited by an animal exposed to cold suggests that fever results from activation of the hypothalamic mechanism requisite for defense against hypothermia, one that mediates reduction in heat loss and increase in heat production. Cats that have long survived truncation of the brain stem below the hypothalamus cannot resist chilling and show no trace of fever when given pyrogen intravenously in doses that cause a marked elevation of body temperature in normal, decorticate, and hypothalamic animals (all of which possess a normal regulation against cold). Microinjections of pyrogen (one one-hundredth the threshold


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