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Reversible Delayed Cutaneous Anergy in Patients with Primary Immunologic Deficiency Syndromes.

C. E. Buckley III, M.D.; P. Imperato, M.D.; and J. L. Callaway, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1140-1141. doi:10.7326/0003-4819-68-5-1140_4
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Studies in two patients with "thymic" type immunologic deficiency states indicate that delayed cutaneous anergy associated with lymphopenia may be reversible. One patient with life-long candida granulomas, normal endocrine function, delayed cutaneous anergy to multiple antigens, impaired homograft rejection, and lymphopenia was treated with parenteral amphotericin B. Improvement of the candidiasis was associated with remission of the delayed cutaneous anergy and lymphopenia. A second patient had unexplained chronic autoaggressive dermatitis, immunoglobulin M (IgM) antinuclear antibody, severely reduced creatinine clearance, and familial dysimmunoglobulinemia associated with a history of allergic diathesis. Lymphopenia and delayed cutaneous anergy remitted during treatment with a completely


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