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The Effect of Antilymphocyte Serum on Experimental Allergic Encephalomyelitis.

Maurice H. Lessof, M.R.C.P.; and Sidney Leibowitz, M.C. Path.
Ann Intern Med. 1968;68(5):1141. doi:10.7326/0003-4819-68-5-1141_1
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One of the earliest observations in the immunosuppressive effect of antilymphocyte serum (ALS) was the demonstration by Waksman that it would influence the course of experimental allergic encephalomyelitis in the guinea pig. Using an antithymocyte serum we have confirmed the powerful suppressive effects of ALS in this disease. Both the neurological signs and the histological lesions were inhibited by short courses of treatment. Treatment that was started after the onset of paralysis was still effective in some cases. Short courses of treatment gave long-term suppression of the neurological signs despite a heavy cellular infiltration of the brain. This contrasted with

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