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Abstracts |

Acute Glutethimide (Doriden®) Intoxication, Hemodialysis Reevaluated.

Joseph A. Chazan, M.D.; and Jordan J. Cohen, M.D.
Ann Intern Med. 1968;68(5):1142. doi:10.7326/0003-4819-68-5-1142_1
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The present study reviews the clinical course of all patients (31) with acute glutethimide intoxication admitted to a community hospital over a 2-year period. The diagnosis was made in each case by the demonstration of elevated blood glutethimide levels; patients with mixed intoxications (including barbiturate and salicylate) were excluded. Thirteen of these 31 patients were responsive on admission and rapidly improved with minimal morbidity and no mortality. Blood glutethimide levels in this group of clinically mild intoxications ranged from 0.9 to 6.4 mg/100 ml. The remaining 18 patients were comatose on admission, and their courses were frequently complicated by hypotension,


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