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Abstracts |

Goiter and Hypothyroidism.

Carl E. Cassidy, M.D.; Richard L. Eddy, M.D.; and Edwin B. Astwood, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1143-1144. doi:10.7326/0003-4819-68-5-1143_3
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Nontoxic goiter, a compensatory phenomenon, reflects a defect in the synthesis of thyroxine. The deficiency stimulates secretion of thyroid-stimulating hormone, enlargement of the thyroid ensues, the daily requirement of thyroxine is met, and the only abnormality that results is the "simple" goiter. We suspected that the compensation should not always be so complete and that goiter and hypothyroidism should sometimes coexist. The suspicion was confirmed by finding 234 patients during a 13-year period.

The frequency of the signs and symptoms was tabulated. Both the protein-bound iodine (PBI) and the 24-hr 131I uptake by the thyroid were carried out in 200


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