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Abstracts |

Pancreatitis, Encephalomalacia, and Hypothermia.

Erskine M. Caperton Jr., M.D.; and Ralph C. Williams Jr., M.D.
Ann Intern Med. 1968;68(5):1145-1146. doi:10.7326/0003-4819-68-5-1145_3
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Many peripheral or systemic manifestations of pancreatitis such as widespread fat necrosis, coagulation disorders, pleural or pericardial effusions, eosinophilia, or hyperlipemia have been extensively documented in clinical reports. Despite the well-known systemic manifestations of acute pancreatic inflammation, little attention has been devoted to central nervous system lesions occurring with pancreatitis. This report concerns six patients who died with acute pancreatitis and were found at autopsy to have distinct acute encephalomalacia including focal areas of brain necrosis (four cases) and neuronal degeneration of internal granular layers of cerebellum (two cases). The pancreatitis-encephalomalacia syndrome was marked by profound terminal hypothermia in three


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