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Abstracts |

Alcohol-Induced Intrahepatic Cholestasis.

George A. Edwards, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1146-1147. doi:10.7326/0003-4819-68-5-1146_3
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Thirty-three cases of alcohol-induced intrahepatic cholestasis were analyzed from histologic, laboratory, and clinical standpoints for the purpose of defining the spectrum of underlying liver disease. Studies were limited to chronic alcoholic patients with laboratory evidence of obstructive jaundice for which there was no obvious extrahepatic cause. Standard liver function tests and conventional light microscopy were employed. Eleven patients had multiple attacks so that observations were made in 51 episodes.

The histological features of acute alcoholic hepatitis—hepatocytonecrosis, hyaline degeneration, and acute inflammation—were present in 14 cases (group A) and absent in 19 (group B). Fatty metamorphosis, portal scarring, and nodular hyperplasia


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