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Immunologic Aspects of Ulcerative Colitis and Regional Enteritis of the Colon.

Richard G. Farmer, M.D., F.A.C.P.; S. D. Deodhar, M.D.; and W. M. Michener, M.D.
Ann Intern Med. 1968;68(5):1147. doi:10.7326/0003-4819-68-5-1147_1
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Increasing evidence has accrued that immunologic mechanisms are important in the etiology of perpetuation of ulcerative colitis. The relationship between ulcerative colitis and regional enteritis of the colon (transmural colitis, granulomatous colitis) has been studied clinically and pathologically, but not immunologically. Sera from 232 patients were analyzed for the presence of colonic, antinuclear, thyroid, and parietal cell antibodies. Group I consisted of 41 patients with ulcerative colitis and 35 patients with regional enteritis of the colon. Group II consisted of 47 patients with other gastrointestinal diseases. In group III were 54 with diseases of "immune cause," and group IV included


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