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Experimental and Clinical Experience with Pancreatic Homotransplantation.

Yasuo Idezuki, M.D.; John A. Feemster, M.D.; Ronald H. Dietzman, M.D.; Robert Ersek, M.D.; Frederick Goetz, M.D.; and Richard C. Lillehei, M.D.
Ann Intern Med. 1968;68(5):1148. doi:10.7326/0003-4819-68-5-1148_1
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Two patients with terminal renal failure and severe diabetes mellitus have received combined cadaver kidney and pancreatic duodenal transplants. One patient survived for 4½ months and did not require insulin to maintain the blood glucose in the normal range while the other lived only 3 weeks. This procedure is soundly based on experimental studies in the dog which show that [1] pancreatectomized dogs can survive for long periods on pancreatic duodenal homografts; [2] when venous drainage of the pancreatic homograft is into the venous system rather than the portal venous system, there is no adverse effect on the activity of

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