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Abstracts |

The Pathogenesis of Acute Tropical Sprue.

William O'Brien, F.R.C.P.
Ann Intern Med. 1968;68(5):1149. doi:10.7326/0003-4819-68-5-1149_1
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The prevalence of tropical sprue among British servicemen and their adult dependents in Southeast Asia presented an opportunity to study the pathogenesis of this syndrome in a young population unaffected by malnutrition, pregnancy, and other extraneous factors. Fifty consecutive patients with uncomplicated sprue were investigated by conventional methods and divided into groups according to the duration of their symptoms. Malabsorption of fat, xylose, and vitamin B12 was found in every patient, including 14 who had been ill for less than 3 months. In this group jejunal biopsies showed a leaf pattern, and histological villous measurements were within normal limits in


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