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A Nonsurgical Test for the Diagnosis of Hirschsprung's Disease.

Marvin M. Schuster, M.D., F.A.C.P.; Fabio Tobon, M.D.; James L. Talbert, M.D.; and Nigel Reid, M.R.C.P.
Ann Intern Med. 1968;68(5):1149. doi:10.7326/0003-4819-68-5-1149_2
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Other than deep rectal biopsy there is no good test that differentiates Hirschsprung's disease (aganglionic megacolon) from other forms of megacolon. In view of the involvement of the internal sphincter in the aganglionosis of this condition, rectosphincteric reflexes were studied in 10 patients with Hirschsprung's disease and compared with 34 normal subjects and with 31 patients with idiopathic megacolon to determine if a difference existed among these three groups. Reflexes were stimulated by transient distention of a rectal balloon and were recorded manometrically by a double balloon device from the internal anal sphincter (smooth muscle) and from the external anal


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