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Ventricular Septal Defect After Myocardial Infarction.

B. C. Campion, M.D.; C. E. Harrison Jr., M.D., F.A.C.P.; E. R. Giuliani, M.D., F.A.C.P.; F. H. Ellis Jr., M.D.; and T. T. Schattenberg, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1152. doi:10.7326/0003-4819-68-5-1152_3
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Of the complications of myocardial infarction, ventricular septal perforation is one that is surgically correctable. Although this is not a common complication, the crescendo-decrescendo holosystolic murmur located at the lower parasternal xyphoid area is sufficiently characteristic to permit early diagnosis. Survival depends on meticulous medical management and proper timing of surgical repair.

Six men (ages 55 to 73 years) with postinfarction ventricular septal defect were observed; five patients had six cardiac catheterizations, and four had cardiac surgery. Summary of catheterization data is as follows (mean plus range): right ventricular pressure, 85/23 (51/8 to 123 per 42) mm Hg; pulmonary artery


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