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Vancomycin Therapy for Bacterial Endocarditis Due to Streptococcus viridans or Enterococcus in Patients Intolerant of Penicillin or Streptomycin.

Charles K. Friedberg, M.D., F.A.C.P.; Kenneth Rosen, M.D.; and Paul Bienstock, M.D.
Ann Intern Med. 1968;68(5):1154-1155. doi:10.7326/0003-4819-68-5-1154_3
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During a single year six patients with bacterial endocarditis due to Streptococcus viridans (two cases) or enterococcus (four cases) were successfully treated with vancomycin. There were no failures. Vancomycin has been effective for staphylococcal endocarditis, but we could find only one reported case of vancomycin cure of S. viridans endocarditis and none of enterococcus endocarditis. In our cases vancomycin was administered either because of a history of serious penicillin allergy or because penicillin or penicillin-streptomycin therapy could not be tolerated. Since vancomycin was effective after only 3 weeks of treatment, it may be considered not only for patients intolerant of

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