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The Long-Term Unnatural History of Cardiopulmonary Changes Following Closure of Left-to-Right Shunts.

Richard D. Lueker, M.D.; John H. K. Vogel, M.D. (Associate); and S. Gilbert Blount Jr., M.D.
Ann Intern Med. 1968;68(5):1158. doi:10.7326/0003-4819-68-5-1158_2
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Detailed information is lacking correlating the clinical and physiologic status of patients who had previously undergone closure of left-to-right shunts. Thirty-six patients were studied up to 11 years postoperation to determine [1] the incidence of reopened left-to-right shunts, [2] the status of ventricular function, and [3] the incidence of abnormal pulmonary vascular reactivity. Twelve patients with patent ductus arteriosus (PDA) were studied an average of 8 years postoperatively. Recanalization of PDAs was noted in 4 patients and was unsuspected in 3. Cardiac output with exercise was abnormal in 1 of 3 patients. Six of 12 subjects had an abnormal increase

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