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A Long-Term Evaluation of the Postexercise Electrocardiogram in the Prediction of Coronary Artery Disease.

L. F. Parmley, M.D., F.A.C.P.; T. W. Mattingly, M.D., F.A.C.P.; and J. A. Orbison, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1160. doi:10.7326/0003-4819-68-5-1160_2
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In 1952 a prospective study was initated at Walter Reed General Hospital to determine if a postexercise electrocardiogram stress test could detect latent coronary artery disease in the clinically normal individual. A retrospective study following extensive use of this exercise test in preceding years had established the electrocardiogram (EKG) criteria of ST segment straightening and depression of over 0.5 mm as indicative of myocardial ischemia and called "ischemic depression" (ID). T-wave changes and ST segment junctional depression were believed due to other than coronary artery disease and called "nonischemic depression" (NID). Three hundred male Army officers, 100 in each of


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