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The Familial Occurrence of the Mid-Late Systolic Click—Late Systolic Murmur Syndrome.

William Shell, M.D.; Park W. Willis III, M.D., F.A.C.P.; Mary E. Clifford, M.D., F.A.C.P.; and Joseph A. Walton Jr., M.D.
Ann Intern Med. 1968;68(5):1161. doi:10.7326/0003-4819-68-5-1161_2
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The pedigrees of 4 families are reported in which mid or late systolic extra sounds, late systolic murmurs, pansystolic murmurs, and abnormal electrocardiograms showed a familial pattern. Each propositus came to attention because of a systolic extra sound and a late systolic murmur. In 31 members of the four families studied, 11 mid or late systolic extra sounds, 7 late systolic murmurs, 8 pansystolic murmurs, and 8 "abnormal" electrocardiograms were found. The prevalence of these abnormalities ranged from 50 to 100% in the 4 families. In 3 of the families there were instances of unexplained sudden death before age 30.


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