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A Quantitative Assessment of Baroreceptor Reflex Sensitivity in Man, Awake and Asleep.

Peter Sleight, M.D.; J. David Bristow, M.D.; A. J. Honour, D.Phil.; George W. Pickering, M.D., F.A.C.P.; and Harley S. Smyth, M.D.
Ann Intern Med. 1968;68(5):1162. doi:10.7326/0003-4819-68-5-1162_1
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An investigation was made of the fall in blood pressure that occurs during a night's sleep. The stage of sleep was identified from the electroencephalogram (five channels), the electrooculogram, and the submental electromyogram. On the last of three successive nights intra-arterial pressure was recorded continuously. Transient reflex bradycardia was produced by the rise in pressure after repeated intravenous injections of 0.25 to 2.0 µg of angiotensin, when subjects were awake and in each successive stage of sleep. The results of each pressor test could be expressed as a straight line in 10 of 13 subjects when the systolic pressures of




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