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The Renin-Angiotensin-Aldosterone System in Hypertension.

D. H. P. Streeten, M.B., D.Phil.; G. V. Clift, M.D.; F. E. Schletter, M.D.; and T. S. Dalakos, M.D.
Ann Intern Med. 1968;68(5):1164. doi:10.7326/0003-4819-68-5-1164_1
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The renin-angiotensin-aldosterone system has been studied in 34 hypertensive and 9 normal subjects, on 200- and 10-mEq sodium diets, recumbent and upright. Significant correlations have been found in normal and essential hypertensive (EH) groups among [1] changes in plasma volume and plasma renin activity (PRA, r = -0.41), [2] log PRA and aldosterone excretion (r = +0.061), [3] log sodium and aldosterone excretion (r = +0.73), and [4] PRA and dose of infused angiotensin needed to raise diastolic back pressure 20 mm Hg (r = +0.58). Patients with EH (19) gave normal results, except for a gentler slope of the


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