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Abstracts |

Hereditary Elliptocytosis: Selected Studies in Genetics and Anemia.

Stuart R. Bless, M.D.; and Paul R. McCurdy, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1164-1165. doi:10.7326/0003-4819-68-5-1164_3
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Because of the limited knowledge of the events leading to hyperhemolysis in a small proportion of patients with hereditary elliptocytosis (HE), 19 affected members of 8 negro families were examined, and 10 members of 3 families were studied in detail. Genetic studies, red blood cell (RBC) life-spans, fragility studies, and 8-µ Millipore® filtrations as well as routine hematological procedures were performed. Three other genetic defects were found in one family—glucose 6-phosphate dehydrogenase deficiency, Marfan's syndrome, and sickle trait, all segregating independently. Most patients were mildly anemic. Reticulocyte counts were normal or slightly elevated. A family with probable linkage between HE


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