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The Role of Erythroid Cell Membranes in Protein Synthesis.

Edward R. Burka, M.D., F.A.C.P.
Ann Intern Med. 1968;68(5):1165-1166. doi:10.7326/0003-4819-68-5-1165_3
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The mammalian erythroid cell is a highly specialized element adapted to the synthesis of predominantly a single protein, hemoglobin. The cell membrane, in addition to maintaining the internal environment of the cell, participates actively in other metabolic activities. These studies define a role for the cell membrane in the metabolism of ribonucleic acid (RNA) and thus the control of protein synthesis in the cell. Approximately 25% of both nonribosomal RNA and ribosomal RNA is bound to the cell membrane. Ribosomes, the site of protein synthesis within the cell, exist in the mammalian reticulocyte in two forms: free and membrane-bound. The


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