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Clinical Significance of the Philadelphia Chromosome in Chronic Granulocytic Leukemia.

George P. Canellos, M.D.; Robert T. Eagan; Jacqueline Whang, M.D.; and Paul P. Carbone, M.D.
Ann Intern Med. 1968;68(5):1166. doi:10.7326/0003-4819-68-5-1166_2
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The Philadelphia (Ph1) chromosome in chronic granulocytic leukemia (CGL) is the only specific cytogenetic defect in human neoplastic disease. Attempts to demonstrate a definite biochemical lesion associated with this abnormality have not, as yet, been successful. Out of a group of 180 consecutive patients admitted to National Cancer Institute with clinical and hematologic features of CGL, 20 (12%) PH1-negative adults were studied. The mean age, sex distribution, and presenting symptomatology did not differ significantly from those of the larger PH1-positive group. One patient had leukemia cutis. The majority (15 of 20) had splenomegaly of some degree. There was a higher

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