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Abstracts |

Hypercoagulability and Fibrinolysis: An Experimental Study.

Daniel Deykin, M.D.; Thomas P. Ashford, M.D.; and Peter Silversmith
Ann Intern Med. 1968;68(5):1167. doi:10.7326/0003-4819-68-5-1167_1
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The clinical syndrome of accelerated intravascular coagulation and simultaneously occurring fibrinolysis is being recognized with increasing frequency. The pathogenesis of the fibrinolytic component of this syndrome remains obscure. The present experiments were undertaken to determine whether activation of the intrinsic coagulation sequence in vivo could itself elicit fibrinolysis. Transient and intense hypercoagulability was produced in anesthetized rabbits by the infusion of normal thrombin-free human serum (1 ml/kg) into the marginal ear veins. Blood samples were drawn before and at intervals after the infusion of serum. The time of onset of coagulation and the rate of fibrin polymerization were determined by


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