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Abstracts |

Platelet Size and Function in Heritable Disorders of Connective Tissue.

J. Worth Estes, M.D.
Ann Intern Med. 1968;68(5):1167-1168. doi:10.7326/0003-4819-68-5-1167_3
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Patients with Marfan, Ehlers-Danlos, Hunter, and Hurler syndromes, osteogenesis imperfecta and pseudoxanthoma elasticum, and their relatives, were evaluated semiquantitatively as to size of their platelets on peripheral blood smears. Considering in turn the total 117 patients and relatives, the 29 available index patients, the total 88 relatives, and the 20 affected relatives, the t test showed that each of these groups had remarkably larger platelets that had 69 normal control subjects (P < 0.02 in all 4 cases). Relatives of index patients with large platelets also tended to have large platelets, and affected relatives had larger platelets than had unaffected

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